Pentapeptide boronic acid inhibitors of Mycobacterium tuberculosis MycP1 protease
نویسندگان
چکیده
منابع مشابه
Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence.
Mycobacterium tuberculosis uses the ESX-1 secretion system to deliver virulence proteins during infection of host cells. Here we report a mechanism of posttranscriptional control of ESX-1 mediated by MycP1, a M. tuberculosis serine protease. We show that MycP1 is required for ESX-1 secretion but that, unexpectedly, genetic inactivation of MycP1 protease activity increases secretion of ESX-1 sub...
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42280. Source: A Tseng, Pharm D, Immunodeficiency Clinic, The Toronto Hospital, Department of Pharmacy, University of Toronto; S Walmsley, MD, Immunodeficiency Clinic, The Toronto Hospital, Department of Medicine, University of Toronto, Toronto ON. MORE ON MANAGEMENT STRATEGIES FOR CANDIDATES FOR PROTEASE INHIBITORS AND REQUIRING TREATMENT FOR MYCOBACTERIUM TUBERCULOSIS In the preceding article...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2014
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2014.05.056